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Airspace geofencing is a key capability for low-altitude Unmanned Aircraft System (UAS) Traffic Management (UTM). Geofenced airspace volumes can be allocated to safely contain compatible UAS flight operations within a fly-zone (keep-in geofence) and ensure the avoidance of no-fly zones (keep-out geofences). This paper presents the application of three-dimensional flight volumization algorithms to support airspace geofence management for UTM. Layered polygon geofence volumes enclose user-input waypoint-based 3-D flight trajectories, and a family of flight trajectory solutions designed to avoid keep-out geofence volumes is proposed using computational geometry. Geofencing and path planning solutions are analyzed in an accurately mapped urban environment. Urban map data processing algorithms are presented. Monte Carlo simulations statistically validate our algorithms, and runtime statistics are tabulated. Benchmark evaluation results in a Manhattan, New York City low-altitude environment compare our geofenced dynamic path planning solutions against a fixed airway corridor design. A case study with UAS route deconfliction is presented, illustrating how the proposed geofencing pipeline supports multi-vehicle deconfliction. This paper contributes to the nascent theory and the practice of dynamic airspace geofencing in support of UTM. 

The primary goal of drug safety researchers and regulators is to promptly identify adverse drug reactions. Doing so may in turn prevent or reduce the harm to patients and ultimately improve public health. Evaluating and monitoring drug safety (i.e., pharmacovigilance) involves analyzing an ever growing collection of spontaneous reports from health professionals, physicians, and pharmacists, and information voluntarily submitted by patients. In this scenario, facilitating analysis of such reports via automation has the potential to rapidly identify safety signals. Unfortunately, public resources for developing natural language models for this task are scant. We present PHEE, a novel dataset for pharmacovigilance comprising over 5000 annotated events from medical case reports and biomedical literature, making it the largest such public dataset to date. We describe the hierarchical event schema designed to provide coarse and fine-grained information about patients’ demographics, treatments and (side) effects. Along with the discussion of the dataset, we present a thorough experimental evaluation of current state-of-the-art approaches for biomedical event extraction, point out their limitations, and highlight open challenges to foster future research in this area.